LITTLE KNOWN FACTS ABOUT PKRRATING.

The activated enzyme then phosphorylates its big substrate, the translational initiation component eIF2α. The resulting translational arrest blocks viral replication. PKR belongs into a conserved household of 4 protein kinases (PKR, PERK, GCN2, HRI) that all phosphorylate eIF2α in response to distinct stimuli12, triggering the integrated pressure